![]() Received: MaAccepted: OctoPublished: November 16, 2021Ĭopyright: © 2021 Zhou et al. PLoS Genet 17(11):Įditor: Li-Jia Qu, Peking University, CHINA (2021) Salt responsive alternative splicing of a RING finger E3 ligase modulates the salt stress tolerance by fine-tuning the balance of COP9 signalosome subunit 5A. Together, these results provide insights that salt-responsive AS acts as post-transcriptional regulation in mediating the function of E3 ligase.Ĭitation: Zhou Y, Li X-H, Guo Q-H, Liu P, Li Y, Wu C-A, et al. Thus, the salt stress-triggered AS controls the ratio of SRAS1.1/SRAS1.2 and switches on and off the degradation of CSN5A to balance the plant development and salt tolerance. By contrast, SRAS1.2 protected CSN5A by competing with SRAS1.1 on the same binding site. The full-length SRAS1.1 promoted degradation of CSN5A by the 26S proteasome. CSN5A is an essential player in the regulation of plant development and stress. In addition, we successfully identified the COP9 signalosome 5A (CSN5A) as the target of SRAS1. 1 made the plants more tolerant to salt stress, whereas overexpression of SRAS1. Comprehensive phenotype analysis showed that overexpression of SRAS1. The salt stress-responsive AS event resulted in greater accumulation of SRAS1. 2, which exhibit opposing responses to salt stress. In this study, we have found that Salt-Responsive Alternatively Spliced gene 1 ( SRAS1), encoding a RING-Type E3 ligase, generates two splicing variants: SRAS1. However, the mechanisms linking these two phenomena remain unclear.
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